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Didangelos T, Karlafti E, Kotzakioulafi E, et al

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The effective dose of Cys, Cys2, and Met against ROS in fibroblast cells generated by paraquat was assessed using laser scanning confocal microscopy

We also provide mechanistic evidence that oxidative stress induces cardiomyocyte ferroptosis by promoting lipid peroxidation via GSH depletion and GPX4 inactivation as well as iron overload through Bach1-HO-1 signaling

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